Article
Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice.
Translational psychiatry - 7 Mar 2024
Mori Daisuke, Ikeda Ryosuke, Sawahata Masahito, Yamaguchi Sho, Kodama Akiko, Hirao Takashi, Arioka Yuko, Okumura Hiroki, Inami Chihiro, Suzuki Toshiaki, Hayashi Yu, Kato Hidekazu, Nawa Yoshihiro, Miyata Seiko, Kimura Hiroki, Kushima Itaru, Aleksic Branko, Mizoguchi Hiroyuki, Nagai Taku, Nakazawa Takanobu, Hashimoto Ryota, Kaibuchi Kozo, Kume Kazuhiko, Yamada Kiyofumi, Ozaki Norio
Abstract excerpt
Whole genome analysis has identified rare copy number variations (CNV) that are strongly involved in the pathogenesis of psychiatric disorders, and 3q29 deletion has been found to have the largest effect size. The 3q29 deletion mice model (3q29-del mice) has been established as a good pathological model for schizophrenia based on phenotypic analysis; however, circadian rhythm and sleep, which are also closely...
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