Article
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.
Molecular psychiatry - 1 Nov 2015
Sidor M M, Spencer S M, Dzirasa K, Parekh P K, Tye K M, Warden M R, Arey R N, Enwright J F, Jacobsen J P R, Kumar S, Remillard E M, Caron M G, Deisseroth K, McClung C A
Abstract excerpt
Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. Moreover, a lack of animal models that display spontaneous cycling between mood states has hindered our mechanistic understanding of mood switching. Here, we find that mice with a mutation in the circadian Clock gene (ClockΔ19) exhibit rapid mood-cycling,...
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