Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.

doi:10.1038/npp.2011.33

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2011

Coque Laurent, Mukherjee Shibani, Cao Jun-Li, Spencer Sade, Marvin Marian, Falcon Edgardo, Sidor Michelle M, Birnbaum Shari G, Graham Ami, Neve Rachael L, Gordon Elizabeth, Ozburn Angela R, Goldberg Matthew S, Han Ming-Hu, Cooper Donald C, McClung Colleen A

Abstract excerpt

Lithium has been used extensively for mood stabilization, and it is particularly efficacious in the treatment of bipolar mania. Like other drugs used in the treatment of psychiatric diseases, it has little effect on the mood of healthy individuals. Our previous studies found that mice with a mutation in the Clock gene (ClockΔ19) have a complete behavioral profile that is very similar to human mania, which can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CLOCK Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dark Adaptation

Share to Lithium Chloride

Share to Locomotion

Share to Maze Learning

Share to Swimming

Share to Tyrosine 3-Monooxygenase

Share to Ventral Tegmental Area

Source

Open in PubMed Open full text

Identifiers

PMID: 21430648
DOI: 10.1038/npp.2011.33
PMCID: PMC3096816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.PMID 21430648Read ↗

Mania-like behavior induced by disruption of CLOCK.Semantic proximity Read ↗

An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.Semantic proximity Read ↗

Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review.Semantic proximity Read ↗

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.Semantic proximity Read ↗

Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitabilitySemantic proximity Read ↗

A mutation in CLOCK leads to altered dopamine receptor function.Semantic proximity Read ↗

Dysfunction of ventral tegmental area GABA neurons causes mania-like behaviorSemantic proximity Read ↗

A novel murine model of maniaSemantic proximity Read ↗

Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.Semantic proximity Read ↗

Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania.Semantic proximity Read ↗

Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area.Semantic proximity Read ↗

Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.