Article
Linking GWAS risk genes to transcriptional features of major depressive disorder via in vivo Perturb-seq.
Nature genetics - 1 Jul 2026
Zhang Liansheng, Kong Xiangrui, Ma Qi, Hu Xinde, Cai Shicheng, Wang Bo, Zou Weijuan, Bai Tao, Zhang Meimei, Fan Liu, Tan Runlin, Dai Ziji, Jia Zhiheng, Li Tianwen, Liu Xingyu, Xu Huatai, Wu Jianrong, Zheng Yuanyi, Xu Zhengzheng, Zhou Haibo
Abstract excerpt
Major depressive disorder (MDD) is a complex disorder with numerous risk genes identified through genome-wide association studies, but their in vivo functions remain unclear. Here we built an in vivo adeno-associated virus (AAV)-Perturb-seq system to perform parallel loss-of-function screening of MDD risk genes in the mouse brain and to define their transcriptional effects and functional relationships. By...
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