Article
Mania-like behavior induced by disruption of CLOCK.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2007
Roybal Kole, Theobold David, Graham Ami, DiNieri Jennifer A, Russo Scott J, Krishnan Vaishnav, Chakravarty Sumana, Peevey Joseph, Oehrlein Nathan, Birnbaum Shari, Vitaterna Martha H, Orsulak Paul, Takahashi Joseph S, Nestler Eric J, Carlezon William A, McClung Colleen A
Abstract excerpt
Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be particularly important. However, the exact role of this gene in the development of this disorder remains unclear. Here we show that mice carrying a mutation in the Clock gene...
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