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Article

Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review.

Molecular psychiatry - 1 Jan 2018

Kristensen M, Nierenberg A A, Østergaard S D

Abstract excerpt

Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl-N-nitrosoure (ENU) mutation (ClockΔ19) are used as an animal model for bipolar disorder (BD). We aimed to systematically review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive validity (responsiveness to treatments used in BD) of this model in adherence with the Preferred Reporting Items for...

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Identifiers

PMID: 29112195
DOI: 10.1038/mp.2017.192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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