Article

Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder

2025-04-01

Abstract excerpt

Bipolar disorder (BD) is a severe psychiatric condition marked by episodes of mania and depression, with neurotransmitter imbalance in the midbrain believed to play a critical role in its pathophysiology. Despite this, there is currently no validated midbrain model for examining BD-associated molecular changes available. Leveraging recent advances in stem cell technology, we developed a midbrain organoid model usi...

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Literature Corpus work: 4c29dc64-70ed-5b7f-8f89-374f8ec4b231
DOI: 10.1101/2025.04.01.646642

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