Article

Results supporting the concept of the oxidant-mediated protein amino acid conversion, a naturally occurring protein engineering process, in human cells

2018-09-28

Abstract excerpt

Reactive oxygen species (ROS) play an important role in the development of various pathological conditions as well as aging. ROS oxidize DNA, proteins, lipids, and small molecules. Carbonylation is one mode of protein oxidation that occurs in response to the iron-catalyzed, hydrogen peroxide-dependent oxidation of amino acid side chains. Although carbonylated proteins are generally believed to be eliminated throug...

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Literature Corpus work: 35e9bff8-f56f-551e-a7e4-3f7e78ca8974
DOI: 10.12688/f1000research.11376.2

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