Article
Protein oxidation in response to increased transcriptional or translational errors.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 2000
Dukan S, Farewell A, Ballesteros M, Taddei F, Radman M, Nyström T
Abstract excerpt
In this study, we show a correlation between synthesis of aberrant proteins and their oxidative modification. The level of aberrant proteins was elevated in Escherichia coli cultures by decreasing transcriptional or translational fidelity using specific mutations or drugs. Protein carbonylation, an oxidative modification, increased in parallel to the induction of the heat shock chaperone GroEL. As the protein...
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