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Protein oxidative modifications in the ageing brain: Consequence for the onset of neurodegenerative disease

6 Sept 2010

Abstract excerpt

The free radical theory of ageing proposes the accumulation of altered, less active and toxic molecules of DNA, RNA, proteins and lipids caused by reactive oxygen species and reactive nitrogen species. Neurodegenerative disorders are characterized by an abnormal accumulation of oxidatively damaged macromolecules inside cells and in the extracellular space. Proteins involved in the formation of aggregates are...

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PMID: 20815785
DOI: 10.3109/10715762.2010.512040

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