Article
Genetically encoding protein oxidative damage.
Journal of the American Chemical Society - 26 Mar 2008
Neumann Heinz, Hazen Jennifer L, Weinstein John, Mehl Ryan A, Chin Jason W
Abstract excerpt
Posttranslational modification of tyrosine residues in proteins, to produce 3-nitrotyrosine (3-NT), is associated with over 50 disease states including transplant rejection, lung infection, central nervous system and ocular inflammation shock, cancer, and neurological disorders (for example, Alzheimer's disease, Parkinson's disease, and stroke). The levels of 3-NT increase in aging tissue, and levels of 3-NT in...
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