Phenotypic and genetic consequences of protein damage.

Abstract excerpt

Although the genome contains all the information necessary for maintenance and perpetuation of life, it is the proteome that repairs, duplicates and expresses the genome and actually performs most cellular functions. Here we reveal strong phenotypes of physiological oxidative proteome damage at the functional and genomic levels. Genome-wide mutations rates and biosynthetic capacity were monitored in real time, in...

Topics

• DNA Damage
• Escherichia coli
• Mutagenesis
• Mutation
• Mutation Rate
• Oxidative Stress
• Phenotype
• Protein Carbonylation
• Proteome
• Reactive Oxygen Species
• Ultraviolet Rays