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Article

PRDX4, an endoplasmic reticulum-localized peroxiredoxin at the crossroads between enzymatic oxidative protein folding and nonenzymatic protein oxidation.

Antioxidants & redox signaling - 1 May 2013

Zito Ester

Abstract excerpt

SIGNIFICANCE: Peroxiredoxin 4 (PRDX4) is an endoplasmic reticulum (ER)-resident peroxiredoxin that has the characteristic of coupling hydrogen peroxide (H(2)O(2)) catabolism with oxidative protein folding. This enzymatic arrangement involves the ingenious use of H(2)O(2) as a substrate to streamline protein metabolism. RECENT ADVANCES: Mice with compound mutations in Prdx4 and Ero1 have revealed the physiological...

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Source

Identifiers

PMID: 23025503
DOI: 10.1089/ars.2012.4966

Genes

PRDX4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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