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Article

Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases

1 Jan 2012

Abstract excerpt

Protein damage mediated by oxidation, protein adducts formation with advanced glycated end products and with products of lipid peroxidation, has been implicated during aging and age-related diseases, such as neurodegenerative diseases. Increased protein modification has also been described upon replicative senescence of human fibroblasts, a valid model for studying aging in vitro. However, the mechanisms by which...

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Share to Antioxidant Activity and Oxidative Stress
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PMID: 23125894
DOI: 10.1155/2012/919832

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