Article
The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
Molecular cell - 4 Nov 2021
Adeyemi Richard O, Willis Nicholas A, Elia Andrew E H, Clairmont Connor, Li Shibo, Wu Xiaohua, D'Andrea Alan D, Scully Ralph, Elledge Stephen J
Abstract excerpt
Protection of stalled replication forks is critical to genomic stability. Using genetic and proteomic analyses, we discovered the Protexin complex containing the ssDNA binding protein SCAI and the DNA polymerase REV3. Protexin is required specifically for protecting forks stalled by nucleotide depletion, fork barriers, fragile sites, and DNA inter-strand crosslinks (ICLs), where it promotes homologous...
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