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Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy

25 Jul 2022

Abstract excerpt

Proliferating cells regularly experience replication stress caused by spontaneous DNA damage that results from endogenous reactive oxygen species (ROS), DNA sequences that can assume secondary and tertiary structures, and collisions between opposing transcription and replication machineries. Cancer cells face additional replication stress, including oncogenic stress that results from the dysregulation of fork...

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PMID: 35897913
DOI: 10.3390/molecules27154736

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