Article

Hidden Structural States of Proteins Revealed by Conformer Selection with AlphaFold-NMR

2024-06-30

Abstract excerpt

We introduce AlphaFold-NMR, a novel approach to NMR structure determination that reveals previously undetected protein conformational states. Unlike conventional NMR methods that rely on NOE-derived spatial restraints, AlphaFold-NMR combines AI-driven conformational sampling with Bayesian scoring of realistic protein models against NOESY and chemical shift data. This method uncovers alternative conformational stat...

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Identifiers and source

Literature Corpus work: 6bcd738b-060b-5651-9102-d74068c6eea2
DOI: 10.1101/2024.06.26.600902

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