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Article

Functional specialization of Ca2+-binding motifs in human MICU1.

International journal of biological macromolecules - 1 Feb 2026

Sommese Leandro Matías, Palopoli Nicolás, Fornasari Maria Silvina, Parisi Gustavo, Gabaldón Toni, Rueda Ana Julia Velez

Abstract excerpt

The mitochondrial Ca2+ uniporter (mtMCU) channel is essential for energy production, cytosolic Ca2+ signaling, and cell death regulation. Calcium dependent proteins MICU1 and MICU2 regulate its activity. To date, twelve MICU1 structures have been experimentally determined. In each, about 30% of the residues are missing, excluding key disordered regions and limiting a complete molecular-level description of the...

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Source

Identifiers

PMID: 41638268
DOI: 10.1016/j.ijbiomac.2026.150702

Genes

MICU1
MICU2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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