Article
Intermotif Communication Induces Hierarchical Ca2+ Filling of Caldendrin.
Biochemistry - 16 May 2017
Kiran Uday, Regur Phanindranath, Kreutz Michael R, Sharma Yogendra, Chakraborty Asima
Abstract excerpt
A crucial event in calcium signaling is the transition of a calcium sensor from the apo (Ca2+ free) to the holo (Ca2+-saturated) state. Caldendrin (CDD) is a neuronal Ca2+-binding protein with two functional (EF3 and EF4) and two atypical (EF1 and EF2), non-Ca2+-binding EF-hand motifs. During the transition from the apo to the holo state, guided by the stepwise filling of Ca2+, the protein passes through distinct...
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