Article

Amphipathic Helices Enable Fatty Acid Uptake and Activation by Human FATP2 at ER Contact Sites

2026-03-27

Abstract excerpt

<title>Abstract</title> <p>Fatty acid transport proteins (FATPs) couple fatty acid uptake to metabolic activation; a process frequently dysregulated in metabolic disease and cancer. However, the structural basis of the coupling has remained unclear. Here we combine native mass spectrometry and cryo-EM to capture fatty acyl-adenylate intermediates and determine the first high-resolution structures of a FATP family...

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Literature Corpus work: bae79040-9170-5706-ab1e-82558060d4e9
DOI: 10.21203/rs.3.rs-8895167/v1

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