Article

Prediction of multiple conformational states by combining sequence clustering with AlphaFold2

2022-10-17

Abstract excerpt

AlphaFold2 (AF2) has revolutionized structural biology by accurately predicting single structures of proteins and protein-protein complexes. However, biological function is rooted in a protein’s ability to sample different conformational substates, and disease-causing point mutations are often due to population changes of these substates. This has sparked immense interest in expanding AF2’s capability to predict c...

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Literature Corpus work: 115104d3-7aff-5d66-8d88-b1c1360bc4e8
DOI: 10.1101/2022.10.17.512570

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