Article

Metformin boosts mitochondria and neurogenesis via AMPK/mTOR/SIRT3 in POLG mutant organoids

2025-06-09

Abstract excerpt

<h4>Background</h4> Mutations in the POLG gene, encoding the catalytic subunit of mitochondrial DNA polymerase gamma, are the most common cause of mitochondrial diseases affecting the central nervous system. These mutations frequently result in neurodevelopmental disorders, yet the cellular and molecular mechanisms underlying POLG related encephalopathies remain poorly understood. In particular, how POLG mutatio...

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Literature Corpus work: 3fc906ec-dc73-50c3-a8a3-c0f65386ed25
DOI: 10.1101/2025.06.08.658480

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