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Advancing CRISPR-Based Programmable Platforms beyond Genome Editing in Mammalian Cells.

ACS synthetic biology - 20 Dec 2019

Higashikuni Yasutomi, Lu Timothy K

Abstract excerpt

Human diseases are caused by dysregulation of cellular biological programs that are encoded in DNA. Unveiling the endogenous programs and encoding new programs into the genome are key to creating novel diagnostic and therapeutic strategies. CRISPR/Cas9, originally identified in bacteria, has revolutionized genome editing in mammalian cells. Recent advances in CRISPR technologies have provided new programmable...

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PMID: 31751114
DOI: 10.1021/acssynbio.9b00297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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