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RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

7 May 2020

Abstract excerpt

BACKGROUND: Prion diseases and prion-like disorders, including Alzheimer's disease and Parkinson's disease, are characterized by gliosis and accumulation of misfolded aggregated host proteins. Ablating microglia in prion-infected brain by treatment with the colony-stimulating factor-1 receptor (CSF-1R) inhibitor, PLX5622, increased accumulation of misfolded prion protein and decreased survival time. METHODS: To...

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PMID: 32381108
DOI: 10.1186/s13041-020-00610-8

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