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Single-cell epigenetic and clonal analysis decodes disease progression in pediatric acute myeloid leukemia

11 Dec 2024

Abstract excerpt

ABSTRACT: Pediatric acute myeloid leukemia (pAML) is a clonal disease with recurrent genetic alterations that affect epigenetic states. However, the implications of epigenetic dysregulation in disease progression remain unclear. Here, we interrogated single-cell and clonal level chromatin accessibility of bone marrow samples from 28 patients with pAML representing multiple subtypes using mitochondrial single-cell...

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PMID: 39661948
DOI: 10.1182/blood.2024025618

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