Article

Identification of GTF2IRD1 as a novel transcription factor essential for acute myeloid leukemia

2022-08-10

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive blood malignancy characterized by clonal accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Transcription factors are the most frequently mutated and dysregulated genes in AML, and they have critical roles in AML pathogenesis and progression. In this study, we performed large-scale RNA interference screens in MLL-AF9 -transformed AML...

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Literature Corpus work: 046ec1dc-f377-5e93-9456-0d9836854487
DOI: 10.1101/2022.08.09.503300

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