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Article

Integrative scATAC-seq and mtDNA mutation analysis reveals disease-driven regulatory aberrations in AML.

Science bulletin - 15 Oct 2025

Tian Chen, Dong Yijun, Sun Xin, Xu Longchen, Ma Xiaoli, Tao Yuwei, Wang Fang, Zhang Haohang, Li Jie, Li Kun, Chen Yasong, Liu Hongxing, Lan Xun

Abstract excerpt

Disturbances in transcriptional regulation during hematopoiesis can lead to aberrant hematopoietic differentiation and potential leukemogenesis. Given the high relapse risk of acute myeloid leukemia (AML), understanding its progression mechanisms and identifying prognostic biomarkers are crucial for improving treatment outcomes. Here, we applied a mitochondrial single-cell assay for transposase-accessible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40781032
DOI: 10.1016/j.scib.2025.07.009

Genes

WT1
GATA4
GRN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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