Article

Pan-cancer silencer transcription atlas reveals leukemia silencer hijacking FOXP1 to enhance <i>MYC</i> oncogene

2026-01-09

Abstract excerpt

Numerous non-coding regulatory elements have been identified in the human genome. However, our understanding of silencers remains largely incomplete. Here, we proposed the concept of silencer transcriptional activity (STA) to investigated silencers from a new perspective using >20,000 transcriptomes. We demonstrated that lower STAs predicted better patient outcomes in most cancers, and a subset of STAs distinguish...

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Literature Corpus work: 6584cfbd-8860-5e25-a89a-aaae6c8248b0
DOI: 10.64898/2026.01.08.698306

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Pan-cancer silencer transcription atlas reveals leukemia silencer hijacking FOXP1 to enhance <i>MYC</i> oncogeneDOI 10.64898/2026.01.08.698306Read

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