Article
SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML.
Blood advances - 11 May 2021
Pacharne Suruchi, Dovey Oliver M, Cooper Jonathan L, Gu Muxin, Friedrich Mathias J, Rajan Sandeep S, Barenboim Maxim, Collord Grace, Vijayabaskar M S, Ponstingl Hannes, De Braekeleer Etienne, Bautista Ruben, Mazan Milena, Rad Roland, Tzelepis Konstantinos, Wright Penny, Gozdecka Malgorzata, Vassiliou George S
Abstract excerpt
Advances in cancer genomics have revealed genomic classes of acute myeloid leukemia (AML) characterized by class-defining mutations, such as chimeric fusion genes or in genes such as NPM1, MLL, and CEBPA. These class-defining mutations frequently synergize with internal tandem duplications in FLT3 (FLT3-ITDs) to drive leukemogenesis. However, ∼20% of FLT3-ITD-positive AMLs bare no class-defining mutations, and...
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