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Article

The somatic molecular evolution of cancer: Mutation, selection, and epistasis.

Progress in biophysics and molecular biology - 1 Oct 2021

Dasari Krishna, Somarelli Jason A, Kumar Sudhir, Townsend Jeffrey P

Abstract excerpt

Cancer progression has been attributed to somatic changes in single-nucleotide variants, copy-number aberrations, loss of heterozygosity, chromosomal instability, epistatic interactions, and the tumor microenvironment. It is not entirely clear which of these changes are essential and which are ancillary to cancer. The dynamic nature of cancer evolution in a patient can be illuminated using several concepts and...

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Identifiers

PMID: 34364910
DOI: 10.1016/j.pbiomolbio.2021.08.003
PMCID: PMC8819680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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