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Article

Peto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jul 2015

Nunney L, Muir B

Abstract excerpt

An evolutionary perspective can help unify disparate observations and make testable predictions. We consider an evolutionary model in relation to two mechanistic frameworks of cancer biology: multistage carcinogenesis and the hallmarks of cancer. The multistage model predicts that cancer risk increases with body size and longevity; however, this is not observed across species (Peto's paradox), but the paradox is...

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Identifiers

PMID: 26056359
DOI: 10.1098/rstb.2015.0161
PMCID: PMC4581038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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