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Article

A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types.

PLoS computational biology - 1 Sept 2015

Cheng Feixiong, Liu Chuang, Lin Chen-Ching, Zhao Junfei, Jia Peilin, Li Wen-Hsiung, Zhao Zhongming

Abstract excerpt

Cancer development and progression result from somatic evolution by an accumulation of genomic alterations. The effects of those alterations on the fitness of somatic cells lead to evolutionary adaptations such as increased cell proliferation, angiogenesis, and altered anticancer drug responses. However, there are few general mathematical models to quantitatively examine how perturbations of a single gene shape...

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PMID: 26352260
DOI: 10.1371/journal.pcbi.1004497
PMCID: PMC4564226

Genes

AHNAK
FAT4
STAG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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