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Article

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.

Nature communications - 3 Dec 2021

Park Solip, Supek Fran, Lehner Ben

Abstract excerpt

The classic two-hit model posits that both alleles of a tumor suppressor gene (TSG) must be inactivated to cause cancer. In contrast, for some oncogenes and haploinsufficient TSGs, a single genetic alteration can suffice to increase tumor fitness. Here, by quantifying the interactions between mutations and copy number alterations (CNAs) across 10,000 tumors, we show that many cancer genes actually switch between...

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Identifiers

PMID: 34862370
DOI: 10.1038/s41467-021-27242-3
PMCID: PMC8642467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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