Article

Clonal lineage tracing of innate immune cells in human cancer

2025-07-21

Abstract excerpt

Innate immune cells constitute the majority of the tumor microenvironment (TME), where they mediate both natural anti-tumor immunity and immunotherapy responses. While single-cell T- and B-cell receptor sequencing has provided fundamental insights into the clonal dynamics of human adaptive immunity, the lack of appropriate tools has precluded similar analysis of innate immune cells. Here, we describe a method that...

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Literature Corpus work: 34fadbf0-368e-56b5-80fa-103214909abc
DOI: 10.1101/2025.07.16.665245

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