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Article

Mitochondrial DNA Mutations as Natural Barcodes for Lineage Tracing of Murine Tumor Models.

Cancer research - 2 Mar 2023

Penter Livius, Ten Hacken Elisa, Southard Jackson, Lareau Caleb A, Ludwig Leif S, Li Shuqiang, Neuberg Donna S, Livak Kenneth J, Wu Catherine J

Abstract excerpt

Murine models are indispensable tools for functional genomic studies and preclinical testing of novel therapeutic approaches. Mitochondrial single-cell assay for transposase-accessible chromatin using sequencing (mtscATAC-seq) enables the dissection of cellular heterogeneity and clonal dynamics by capturing chromatin accessibility, copy-number variations (CNV), and mitochondrial DNA (mtDNA) mutations, yet its...

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Identifiers

PMID: 36469010
DOI: 10.1158/0008-5472.CAN-22-0275
PMCID: PMC9988704

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