Article
Clonal lineage tracing of innate immune cells in human cancer.
Cancer cell - 13 Jul 2026
Liu Vincent, Sandor Katalin, Yan Patrick K, Miao Zhuang, Yin Yajie, Stickels Robert R, Chen Andy Y, Hiam-Galvez Kamir, Gutierrez Jacob, Zhang Wenxi, Sajjath Sairaj M, Valbuena Raeline, Wang Steven, Daniel Bence, Ludwig Leif S, Howitt Brooke E, Lareau Caleb A, Satpathy Ansuman T
Abstract excerpt
Innate immune cells constitute the majority of the tumor microenvironment (TME) and mediate anti-tumor immunity and immunotherapy responses. While single-cell T and B cell receptor sequencing have revealed insights into the clonal dynamics of adaptive immunity, the lack of analogous tools has precluded similar analysis of innate immune cells. Here, we describe a method leveraging somatic mitochondrial DNA (mtDNA)...
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