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Article

YAP/TAZ inhibition refines TGF-β signaling to prevent laryngeal fibrosis

2026-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Voice disorders affect nearly 20 million Americans and cost more than $13 billion annually. Vocal fold (VF) fibrosis, a major cause of chronic dysphonia, disrupts normal vocal fold vibration by replacing the flexible extracellular matrix with stiff fibrotic tissue. Although TGF-β drives fibrosis, it also activates intrinsic negative feedback mechanisms, including SMAD7 induction and SMAD3 downre...

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Literature Corpus work
34e737c9-8766-5c02-a67f-7cb4609cb0de
DOI
10.64898/2026.05.18.726086
Open publication

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YAP/TAZ inhibition refines TGF-β signaling to prevent laryngeal fibrosisDOI 10.64898/2026.05.18.726086
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