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Article

Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF

4 Jun 2022

Abstract excerpt

Long non-coding RNA (lncRNA) was reported to be a critical regulator of cellular homeostasis, but poorly understood in idiopathic pulmonary fibrosis (IPF). Here, we systematically identified a crucial lncRNA, p53-induced long non-coding RNA TP53 target 1 (TP53TG1), which was the dysregulated hub gene in IPF regulatory network and one of the top degree genes and down-regulated in IPF-drived fibroblasts. Functional...

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PMID: 35661695
DOI: 10.1038/s41419-022-04975-7

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