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Tankyrase inhibition demonstrates anti-fibrotic effects in preclinical pulmonary fibrosis models

2025-11-13

Abstract excerpt

<h4>Background</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited treatment options. Although transforming growth factor beta 1 (TGFB1, TGFβ) is a key driver of fibrosis, additional signaling pathways, including wingless-type mammary tumor virus integration site (WNT)/β-catenin and yes-associated protein 1 (YAP), contribute to IPF pathogenesis. Clinical data indicate tha...

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Literature Corpus work
40031265-c481-5f87-8070-9cc684a5a8e7
DOI
10.1101/2025.11.13.688191
Open publication

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Tankyrase inhibition demonstrates anti-fibrotic effects in preclinical pulmonary fibrosis modelsDOI 10.1101/2025.11.13.688191
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