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Article

Transcriptomic changes during TGF-β-mediated differentiation of airway fibroblasts to myofibroblasts

30 Dec 2019

Abstract excerpt

Asthma is the most common chronic lung disease in children and young adults worldwide. Airway remodelling (including increased fibroblasts and myofibroblasts in airway walls due to chronic inflammation) differentiates asthmatic from non-asthmatic airways. The increase in airway fibroblasts and myofibroblasts occurs via epithelial to mesenchymal transition (EMT) where epithelial cells lose their tight junctions...

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PMID: 31889146
DOI: 10.1038/s41598-019-56955-1

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