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Article

FAM13A as potential therapeutic target in modulating TGF-β-induced airway tissue remodeling in COPD

9 Jun 2021

Abstract excerpt

Genome-wide association studies have shown that a gene variant in the Family with sequence similarity 13, member A (FAM13A) is strongly associated with reduced lung function and the appearance of respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD). A key player in smoking-induced tissue injury and airway remodeling is the transforming growth factor-β1 (TGF-β1). To determine the role...

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PMID: 34105356
DOI: 10.1152/ajplung.00477.2020

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