Article
A genome-wide association study of serum proteins reveals shared loci with common diseases.
Nature communications - 25 Jan 2022
Gudjonsson Alexander, Gudmundsdottir Valborg, Axelsson Gisli T, Gudmundsson Elias F, Jonsson Brynjolfur G, Launer Lenore J, Lamb John R, Jennings Lori L, Aspelund Thor, Emilsson Valur, Gudnason Vilmundur
Abstract excerpt
With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of most disease associated alleles is not understood. The measurement of protein level variation in solid tissues and biofluids integrated with genetic variants offers a path to deeper functional insights. Here we present a large-scale proteogenomic study in...
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