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Article

Synergistic insights into human health from aptamer- and antibody-based proteomic profiling.

Nature communications - 24 Nov 2021

Pietzner Maik, Wheeler Eleanor, Carrasco-Zanini Julia, Kerrison Nicola D, Oerton Erin, Koprulu Mine, Luan Jian'an, Hingorani Aroon D, Williams Steve A, Wareham Nicholas J, Langenberg Claudia

Abstract excerpt

Affinity-based proteomics has enabled scalable quantification of thousands of protein targets in blood enhancing biomarker discovery, understanding of disease mechanisms, and genetic evaluation of drug targets in humans through protein quantitative trait loci (pQTLs). Here, we integrate two partly complementary techniques-the aptamer-based SomaScan® v4 assay and the antibody-based Olink assays-to systematically...

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Identifiers

PMID: 34819519
DOI: 10.1038/s41467-021-27164-0
PMCID: PMC8613205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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