Article
Cross-ancestry comparison of aptamer and antibody protein measures.
Nature communications - 22 Jan 2026
Nicholas Jayna C, Katz Daniel H, Tahir Usman A, Debban Catherine L, Aguet Francois, Blackwell Thomas, Bowler Russell P, Broadaway K Alaine, Chen Jingsha, Clish Clary B, Coresh Josef, Cornell Elaine, Cruz Daniel E, Deo Rajat, Doyle Margaret F, Durda Peter, Ekunwe Lynette, Floyd James S, Gill Dipender, Guo Xiuqing, Hoogeveen Ron C, Johnson Craig, Lange Leslie A, Li Yun, Manning Alisa, Meigs James B, Mi Michael Y, Mychaleckyj Josyf C, Olson Nels C, Pratte Katherine A, Psaty Brucy M, Reiner Alexander P, Ruan Peifeng, Sevilla-Gonzalez Magdalena, Shah Amil M, Sun Quan, Tracy Russell P, Wen Jia, Wood Alexis C, Wilson James G, Young Kristin L, Yu Bing, Rooney Mary R, Manichaikul Ani, Dubin Ruth, Mohlke Karen L, Rich Stephen S, Rotter Jerome I, Ganz Peter, Gerszten Robert E, Taylor Kent D, Raffield Laura M
Abstract excerpt
Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants and phenotypes. Here, we examine 2157 proteins measured on both SomaScan 7k and Olink Explore 3072 across 1930 participants with genetic similarity to European, African, East Asian, and Admixed American ancestry references. Inter-platform correlation coefficients for these...
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