Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking

19 Jun 2025

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) remodels the host chromatin structure and induces a host-to-virus transcriptional switch during lytic infection. We combine super-resolution imaging and chromosome-capture technologies to identify the mechanism of remodeling. We show that the host chromatin undergoes massive condensation caused by the hijacking of RNA polymerase II (RNAP II) and topoisomerase I (TOP1). In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Poxvirus research and outbreaks
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40537528
DOI: 10.1038/s41467-025-60534-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijackingPMID 40537528Read ↗

CTCF interacts with the lytic HSV-1 genome to promote viral transcriptionSemantic proximity Read ↗

Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcriptionSemantic proximity Read ↗

Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcriptionSemantic proximity Read ↗

Kaposi’s sarcoma–associated herpesvirus stably clusters its genomes across generations to maintain itself extrachromosomallySemantic proximity Read ↗

CTCF and Rad21 Act as Host Cell Restriction Factors for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Replication by Modulating Viral Gene TranscriptionSemantic proximity Read ↗

Microtubule mechanotransduction refines cytomegalovirus interactions with and remodeling of host chromatinSemantic proximity Read ↗

Chromatin dynamics during herpes simplex virus-1 lytic infectionSemantic proximity Read ↗

Superresolution microscopy reveals structural mechanisms driving the nanoarchitecture of a viral chromatin tetherSemantic proximity Read ↗

Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B CellsSemantic proximity Read ↗

SARS-CoV-2 Restructures the Host Chromatin ArchitectureSemantic proximity Read ↗

Specific Virus-Host Genome Interactions Revealed by Tethered Chromosome Conformation CaptureSemantic proximity Read ↗

Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.