Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional genomics identifies therapeutic targets for MYC-driven cancer

23 May 2012

Abstract excerpt

MYC oncogene family members are broadly implicated in human cancers, yet are considered "undruggable" as they encode transcription factors. MYC also carries out essential functions in proliferative tissues, suggesting that its inhibition could cause severe side effects. We elected to identify synthetic lethal interactions with c-MYC overexpression (MYC-SL) in a collection of ~3,300 druggable genes, using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroblastoma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22623531
DOI: 10.1073/pnas.1121119109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional genomics identifies therapeutic targets for MYC-driven cancerPMID 22623531Read ↗

Identification and Pharmacological Inactivation of the MYCN Gene Network as a Therapeutic Strategy for Neuroblastic Tumor CellsSemantic proximity Read ↗

Taking on challenging targets: making MYC druggable.Semantic proximity Read ↗

Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastomaSemantic proximity Read ↗

CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer driversSemantic proximity Read ↗

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule CompoundsSemantic proximity Read ↗

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastomaSemantic proximity Read ↗

Synthetic lethal screens as a means to understand and treat MYC-driven cancers.Semantic proximity Read ↗

Inhibition of CDK4 as a potential therapy for natural killer cell lymphoma with MYC overexpressionSemantic proximity Read ↗

Highly parallel identification of essential genes in cancer cellsSemantic proximity Read ↗

The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cellsSemantic proximity Read ↗

c-Myc as a therapeutic target in cancerSemantic proximity Read ↗

MYC: there is more to it than cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.