Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening

Abstract excerpt

Many gene fusions have been reported in tumours and for most their role remains unknown. As fusions can be used clinically for diagnostic and prognostic purposes, and are targets for treatment, it is crucial to assess their functional implications in cancer. To investigate the role of fusions in tumor cell fitness, we developed a systematic analysis utilising RNA-sequencing data from 1,011 human cancer cell lines...

Topics

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• Cytogenetic Analysis
• Gene Expression Regulation, Neoplastic
• Gene Fusion
• Gene Regulatory Networks
• Genetic Techniques
• High-Throughput Nucleotide Sequencing
• In Situ Hybridization, Fluorescence
• Ovarian Neoplasms

Identifiers and source

Literature Corpus work

d8b96b5d-8c8a-552f-84c4-e47d6e24f1d2

DOI

10.1101/559690