Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The kinetochore and cancer: what's the connection?

Current opinion in cell biology - 1 Dec 2005

Yuen Karen W Y, Montpetit Ben, Hieter Philip

Abstract excerpt

The molecular mechanisms ensuring accurate chromosome segregation during meiosis and mitosis are critical to the conservation of euploidy (normal chromosome number) in eukaryotic cells. A dysfunctional kinetochore represents one possible source for chromosome instability (CIN) and the generation of aneuploidy. The kinetochore is a large complex of proteins and associated centromeric DNA that is responsible for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Instability
Share to Kinetochores
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Source

Identifiers

PMID: 16233975
DOI: 10.1016/j.ceb.2005.09.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The kinetochore and cancer: what's the connection?PMID 16233975Read ↗

Chromosome instability and kinetochore dysfunction.Semantic proximity Read ↗

Kinetochore Malfunction in Human Pathologies.Semantic proximity Read ↗

Unraveling pathologies underlying chromosomal instability in cancers.Semantic proximity Read ↗

Analysis of kinesin motor function at budding yeast kinetochores.Semantic proximity Read ↗

Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screensSemantic proximity Read ↗

Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.Semantic proximity Read ↗

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.Semantic proximity Read ↗

Inducing Specific Chromosome Mis-Segregation in Human CellsSemantic proximity Read ↗

On the road to cancer: aneuploidy and the mitotic checkpoint.Semantic proximity Read ↗

Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotesSemantic proximity Read ↗

The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.Semantic proximity Read ↗

Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.