Functional unknomics: closing the knowledge gap to accelerate biomedical research

Abstract excerpt

<h4>Summary</h4> The human genome encodes ∼20,000 proteins, many still uncharacterised. Scientific and social factors have resulted in a focus on well-studied proteins, leading to a concern that poorly understood genes are unjustifiably neglected. To address this, we have developed an “Unknome database” that ranks proteins based on how little is known about them. We applied RNAi in Drosophila to 260 unknown gene...

Topics

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• CRISPR-Cas Systems
• Gene Editing
• Gene Expression Profiling
• Gene Regulatory Networks
• Genetic Association Studies
• Genetics, Aging, and Longevity in Model Organisms
• Genome, Human
• Genomics

Identifiers and source

Literature Corpus work

87f0ed6c-ad91-54f2-a57f-0a0b41337a78

DOI

10.1101/2022.06.28.497983