Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.

The Journal of cell biology - 11 Jan 2010

Vizeacoumar Franco J, van Dyk Nydia, S Vizeacoumar Frederick, Cheung Vincent, Li Jingjing, Sydorskyy Yaroslav, Case Nicolle, Li Zhijian, Datti Alessandro, Nislow Corey, Raught Brian, Zhang Zhaolei, Frey Brendan, Bloom Kerry, Boone Charles, Andrews Brenda J

Abstract excerpt

We describe the application of a novel screening approach that combines automated yeast genetics, synthetic genetic array (SGA) analysis, and a high-content screening (HCS) system to examine mitotic spindle morphogenesis. We measured numerous spindle and cellular morphological parameters in thousands of single mutants and corresponding sensitized double mutants lacking genes known to be involved in spindle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Automation, Laboratory
Share to Genetic Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Binding

Share to Protein Interaction Mapping

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Spindle Apparatus

Share to SUMO-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20065090
DOI: 10.1083/jcb.200909013
PMCID: PMC2812844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.PMID 20065090Read ↗

Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screensSemantic proximity Read ↗

Genome-wide synthetic lethal screens identify an interaction between the nuclear envelope protein, Apq12p, and the kinetochore in Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways.Semantic proximity Read ↗

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.Semantic proximity Read ↗

The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.Semantic proximity Read ↗

Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.Semantic proximity Read ↗

The phenotypic landscape of essential human genes.Semantic proximity Read ↗

Identification of protein complexes required for efficient sister chromatid cohesion.Semantic proximity Read ↗

Identification of Saccharomyces cerevisiae spindle pole body remodeling factors.Semantic proximity Read ↗

A global genetic interaction network by single-cell imaging and machine learning.Semantic proximity Read ↗

The phenotypic landscape of essential human genesSemantic proximity Read ↗

Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.